No, you got your lab mouse on my human stem cell culture!
The New York Times has an editorial today about
the emerging science of "chimeras", meaning the blending of one species with another, using bioengineering. This can be as simple as engineering lab rats with human genes, or even growing human organs in pigs.
Like with so many new technologies, it has a lot of potential to provide many benefits, but it does of course raise some serious ethical considerations.
For example, consider the above. In order to evaluate how stem cells become brain and nervous system tissue
in vivo, (rather than in culture,) they could take these human stem cell cultures and implant them in mouse embryos. But couldn't that, in theory, lead to a human brain "trapped" inside a mouse's body?
That's just one example of many.
The editorial puts forward the idea that most of the actual experiments being done are rather mundane and that the ethical considerations for them are nearly moot, and that we run the risk of banning some very useful science with a knee-jerk reaction to experiments which are not necessarily ever going to become an issue.
I'm somewhat sympathetic to that point of view, even if I'm not as fully committed to it as the editorial writer is, but the editorial is frankly not the most persuasive writing I've seen on the subject.
To me, I find myself strongly ambivalent on the issue. The science/bioengineering geek in me thinks that the whole thing is pretty cool, and could lead to all sorts of advances in both biology and medicine. That said, I think that there are still serious ethical and moral considerations to make. Though the idea that we'll end up with a "human trapped in a mouse" is actually pretty far-fetched, the truth of the matter is that experiments like these do start to blur the lines a little between what is "animal" and what is "human".
How "human" does an organism have to be in order to qualify for the legal rights and standards associated with that classification? Chimps and dolphins for example, are pretty smart. How much smarter would they have to be before we consider them "intelligent" creatures deserving of legal protection? And can intelligence be the only determining factor? To be sure, there are some humans who, through disease or injury, have extremely limited mental capacities, get we generally consider them to have the full spectrum of human rights, (or at least, more than animals have.)
I think it can all get very tricky. How do we balance potential abuses and problems with potential benefits and advances in quality of life? It's all fine and good to say we shouldn't do this kind of research, but what if that research could eventually save hundreds or even thousands of lives? I don't know the answer, but you can bet I'll be following the debate.